2018-06-29

Pre-Clinical Manufacturing Specialist
Job Opportunity at Spark Therapeutics, Inc

Posted on Jun 29

http://www.sparktx.com    215-220-9300

Location: Philadelphia, PA
Job Type: Full Time
Job ID: W4151233

This position is a key participant in the day-to-day operation and planning of rAAV vector production related work, with primary responsibility to execute established protocols of manufacturing research and pre-clinical grade rAAV vectors.  The individual in the role will participate in (but not be limited to) manufacturing of rAAV vectors including cell culture, vector production and purification, and rAAV related assays. Additionally, the individual will contribute to the implementation of documentation in order to support research and GLP rAAV vector manufacturing.
 
This position requires good knowledge and experience with cell culture and good knowledge and skills related to purification of bio-products and related assays. Good written and verbal communication skills and ability to work effectively in a team environment are required.
 
RESPONSIBILITIES:
70%       
  • Hands-on manufacture of AAV vectors in assisting upstream virus production, downstream purification and assays of rAAV vectors
10%       
  • Prepare laboratory reagents/raw materials for the manufacturing of research and pre-clinical grade rAAV vectors
15%       
  • Participate in investigations
  • Review and revise SOPs and batch records for virus production and purification
  • Perform routine calculations and maintain appropriate records
  • Maintain manufacturing equipment and records
  • Maintain laboratory safety procedures and compliance records
5%         
  • Participate in other projects upon request

QUALIFICATIONS:
  • Value research integrity and collaborative research
  • Strong interpersonal, communication, analytical, and critical thinking skills, including being able to adapt to work areas requiring various intellectual and professional approaches
  • Excellent organizational and time management skills

REQUIREMENTS:
  • A Bachelor's degree or M. S. degree in biology, biomedical, cell biology, or engineering
  • Generally 2-5 years of relevant working experience
  • Experience with large scale cell culture or protein purification
  • Experience in industry laboratory using GLP/ GMP
  • High degree of flexibility of skills and hours
  • Thorough knowledge of Microsoft Office suite
  • Must be able to lift 25 pounds

WHO WE ARE:

Transforming Patient’s Lives. Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.




















































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